Ultrasonographic features of pure ductal carcinoma in situ of the breast : correlations with pathologic features and biological markers
Ultrasonographic features of pure ductal carcinoma in situ of the breast : correlations with pathologic features and biological markers / Hwajin Cha, Yun-Woo Chang, Eun Ji Lee, Ji Young Hwang, Hyun Joo Kim, Eun Hye Lee, Jung Kyu Ryu
p. 307-314 ; 29cm
수록자료: Ultrasonography. Seoul Korean Society of Ultrasound in Medicine. Vol.37 no.4(2018 October), p. 307-314 37:4<307 ISSN 2288-5919↔ 저자: Hwajin Cha, Department of Radiology, Soonchunhyang University Seoul Hospital 저자: Yun-Woo Chang, Department of Radiology, Soonchunhyang University Seoul Hospital 저자: Eun Ji Lee, Department of Radiology, Soonchunhyang University Seoul Hospital 저자: Ji Young Hwang, Department of Radiology, Soonchunhyang University Seoul Hospital 저자: Hyun Joo Kim, Department of Radiology, Soonchunhyang University Seoul Hospital 저자: Eun Hye Lee, Department of Radiology, Soonchunhyang University Bucheon Hospital 저자: Jung Kyu Ryu, Department of Radiology, Kyung Hee University Hospital at Gangdong
Purpose: The purpose of this study was to evaluate the ultrasonographic features of pure ductalcarcinoma in situ (DCIS) of the breast and to evaluate the correlations of ultrasonographicfeatures with pathologic and biological features. Methods: A total of 141 lesions in 138 women with pure DCIS who underwent preoperativebreast ultrasonography were retrospectively reviewed. Ultrasonographic features were analyzedusing the American College of Radiology Breast Imaging Reporting and Data System (BI�RADS) ultrasonography lexicon and the diagnostic criteria of the Japan Society of Ultrasonics inMedicine. Pathologic features including the nuclear grade and presence of comedonecrosis wereevaluated. Biological markers including estrogen receptor, progesterone receptor, and humanepidermal growth factor receptor 2 (HER2) status, as well as the Ki-67 index, were recorded. Ultrasonographic features were compared with pathologic findings and biological markers usingthe chi-square test. P-values of <0.05 were considered to indicate statistical significance. Results: Of the 141 lesions, 75 (53.2%) were mass lesions, 56 (39.7%) were non-mass lesions,and 10 (7.1%) were not visible. The most common feature of the mass pattern was a masswith irregular shape (32.6%), an indistinct margin (27.7%), and hypoechogenicity (37.6%). Microcalcifications were observed in 48 cases (36.6%) as an associated feature. Calcificationsoutside of a mass were more common than calcifications within a mass. Ultrasonographicmicrocalcifications and ductal changes were frequently observed in non-mass lesions. Ultrasonographic non-mass lesions were associated with high-grade DCIS (P=0.004) and thepresence of comedonecrosis (P=0.006). Microcalcifications were significantly associated withhigh-grade DCIS (P<0.001), the presence of comedonecrosis (P<0.001), an elevated Ki-67(P<0.001), and HER2 positivity (P=0.003). Conclusion: The most common ultrasonographic feature of pure DCIS was an irregular, hypoechoicmass with an indistinct margin. Ultrasonographic microcalcifications and ductal changes weremore frequent in non-mass lesions, which were correlated with poor prognostic factors, such as ahigh nuclear grade, comedonecrosis, HER2 positivity, and an elevated Ki-67 index.