Chiral pool synthesis of N-Cbz-cis-(3R, 4R)-3-methylamino-4-methylpiperidine from L-malic acid
Chiral pool synthesis of N-Cbz-cis-(3R, 4R)-3-methylamino-4-methylpiperidine from L-malic acid / Bao-Yu Hao, Jin-Qiang Liu, Wei-Han Zhang, Xin-Zhi Chen
p. 1371-1377 ; 28 cm
수록자료: Bulletin of the Korean Chemical Society. Korean Chemical Society. Vol.34 No.5(2013 May). p. 1371-1377 34:5<1371 ISSN 0253-2964 저자: Bao-Yu Hao, Department of Chemical and Biological Engineering, Zhejiang University ; Hutchison MediPharma Limited 저자: Jin-Qiang Liu, College of Chemistry and Chemical Engineering, Luoyang Normal University E-MAIL: firstname.lastname@example.org 저자: Wei-Han Zhang, Hutchison MediPharma Limited 저자: Xin-Zhi Chen, Department of Chemical and Biological Engineering, Zhejiang University
A new synthetic route to N-Cbz-cis-(3R,4R)-3-methylamino-4-methylpiperidine, key intermediate for CP-690,550, was disclosed with L-malic acid as the chiral pool starting material. The title compound was obtained in 16 steps with a total yield of 26% and more than 98% ee.